Q
Why do we have different reactions to caffeine?
A
Expert Answer
Caffeine sensitivity varies due to: genetics (CYP1A2 metabolizes caffeine; ADORA2A affects anxiety response), tolerance from regular use, body weight, liver function, pregnancy (slows metabolism), and medications. Some people feel anxious from small amounts; others can drink coffee before bed.
Key Insight
Caffeine sensitivity varies due to: genetics (CYP1A2 metabolizes caffeine; ADORA2A affects anxiety response), tolerance from regular use, body weight, liver function, pregnancy (slows metabolism), and medications.
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